Cellular engineering (and propietary Cell farming) vertical of Pandorum essentially deals with the expansion of stem cells form different tissue sources in a robust and scalable manner. Pandorum’s expertise to culture cells in 2D or 3D environment for optimized cellular expression for production of cell and cell derived components with therapeutic potential is key to various product formulation with regenerative capacities.
Video-microscopy data captured in Pandorum’s lab (MUSC) shows cellular level events leading to wound healing, using Exosome stimulated migration of Corneal Epithelial Cells, covering the zone of separation ~300 micron (marked by the dotted line) created in a scratch assay. The arrow at different time points shows a small ‘pillar’ of leader cells- first ones to bridging the gap
Bioprinting is the hierarchical assembly of 3D biological structures for tissue construction. Pandorum leverages this state of the art extrusion-based bioprinter to mimic microenvironment and architecture of human tissues. “Time”, when integrated as the fourth dimension, the printed structure dynamically changes its form to express tissue-specific functionalities. Pandorum combines various fabrication processes in its product development pipelines to ‘build the blocks of life’.